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Validation of human skeletal actin (HSA) natLSP-IL15 and HSA-IL2SP-IL15 transgenic mouse lines. A and B: schematic maps of HSA-natLSP-IL15 (A) and HSA-IL2SP-IL15 (B) transgenes. C–F: interleukin-15 (IL-15) mRNA expression in various tissues of control (CON) and transgenic (TG) mice, determined by real-time PCR. LSP, long signal peptide; SP, signal peptide. Bars show means ± SE; n = 4–5 mice/group; differences between control and transgenic: *P < 0.05, **P < 0.01, and ***P < 0.001.
