Table 3.

Leucine kinetics during Hyper-1 and Hyper-3 clamps

	Hyper-1		Hyper-3
	Basal	Clamp	Basal	Clamp
Total Ra (flux)	140.4±4.8	167.5±7.1‡	138.0±5.1	251.9±9.3†‡
Oxidation	33.6±1.4	37.2±1.7	27.0±1.2	95.8±5.1†‡
Endogenous Ra (breakdown)	140.4±4.8	115.3±6.3‡	138.0±5.1	100.2±6.7‡
Exogenous Ra (infusion rate)		52.0±1.6		151.7±10.0†
Nonoxidative Rd (synthesis)	106.8±3.5	130.3±6.7‡	110.9±4.1	156.2±6.2*‡
Nonoxidative Rd − endogenous Ra (net balance)	−33.6±1.4	15.0±1.3‡	−27.0±1.2	55.9±6.2†‡

Values (in μmol/min) are means ± SE.

^*P < 0.05,

^†P < 0.001 vs. Hyper-1 clamp period, by independent t-tests.

^‡P< 0.01 vs. corresponding basal values, by paired t-test.