Table 3.

Stepwise multiple regression analysis of the major determinants of leukocyte DNA 8-OHdG level in 488 hemodialysis patients^a

Variable	Regression Coefficient	95% CI	P
GST M1 genotype
GST M1(−) versus GST M1(+)	0.325	0.238 to 0.411	<0.001
hOGG1 1245C→G genotypeb
1245CG	0.388	0.264 to 0.511	<0.001
1245GG	0.763	0.634 to 0.891	<0.001
Dialyzer membrane typec
PMMA membrane	−0.226	−0.349 to −0.103	<0.001
PS membrane	−0.445	−0.560 to −0.330	<0.001
vitamin E–bonded membrane	−0.864	−1.502 to −0.677	<0.001
Ascorbate per 1 mg/L	−0.201	−0.304 to −0.140	<0.001 (1)
WB GSH/hematocrit
per 1 μmol/L per % hematocrit	−0.190	−0.231 to −0.075	<0.001 (2)
Age per 1 yr	0.004	0.001 to 0.007	<0.001 (3)
Current smoking status
smoker versus nonsmoker	0.195	0.084 to 0.310	0.009 (4)
Diabetes
presence versus absence	0.114	0.045 to 0.279	0.017 (5)
α-Tocopherol/cholesterol per 1 mg/g	−0.083	−0.113 to −0.052	0.034 (6)
ln-ferritin per ln-1 μg/L	0.075	0.046 to 0.105	0.045 (7)

^aThe dependent variable is ln leukocyte DNA 8-OHdG level. Order of appearance in the equation in parentheses.

^bThe 1245CC genotype was the reference category for the 1245CG and 1245GG genotypes.

^cThe cellulose membrane was the reference category for the PMMA, PS, and vitamin E–bonded membranes.