Table 1.
Pathologic findings in MPO-deficient micea
Group | Mice with Crescents (% [n]) | % Glomeruli with Crescents per Mouse
|
% Glomeruli with Necrosis per Mouse (Mean ± SEM)
|
% Engraftment with MPO-Positive PMN (Mean ± SEM)
|
|||
---|---|---|---|---|---|---|---|
Mean ± SEM | Range (%) | Mean ± SEM | Range (%) | Mean ± SEM | Range (%) | ||
WT | 100 (6/6)b | 11.3 ± 3.4b | 5.4 to 24.1 | 6.1 ± 1.8b | 3.2 to 14.5 | 91.3 ± 3.2 | 80 to 100 |
C5aR−/− | 12.5 (1/8) | 0.5 ± 0.3 | 0.0 to 2.1 | 0.0 ± 0.0 | 91.5 ± 6.3 | 82 to 100 |
Mice received WT or C5aR−/− BM.
P < 0.01.