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Determination of the antithrombotic and PAR-1-mediated properties of variants of APC. (A) Concentration dependence of wt-APC and variants L8W and K193E in a plasma APTT determination. Results are expressed as seconds of prolongation of the clotting time. Results are the mean ± SD, n = 8. (B) Effect of wt-APC, K193E, and L8W on permeability deficit in HUVECs by the Evans blue dye method described previously.21 Results are mean ± SEM, n = 4.
