Figure 9.

Effect of APC on caspase-3 activation and differential PAR-1 modulation. (A) Determination of degree of active caspase-3 in renal tissue and effect of APC and variant treatments (100 μg/kg). (B) Schematic of APC's distinct effects on PAR-1 agonism (K193E), and suppression of thrombin-mediated PAR-1 agonism by inhibition of thrombin generation (L8W). Redundant mechanisms appear to allow APC to improve vascular function because both variants improve renal blood flow and function by modulating distinct pathways.