Table 2.

Many features of computer information retrieval process, designed to minimize latency incurrence, are also found in cells. These features, in conjunction with decoupling of steps of the retrieval process, help explain discrepancy in RNA and protein abundance.

Computer			Cell		Potential Discrepancy
Step	Action	Feature	Action	Feature	Potential Discrepancy
Storage To Memory	Load	By page	Transcription	Operon; Regulon	Higher RNA level, steady protein level
	Load	Spatial locality: working set	Transcription	Parallel signaling pathways	Higher RNA level, steady protein level
	Purge	By page	RNA degradation	Degradation PTRO	Lower RNA level, steady protein level
	Purge	Temporal locality	RNA degradation	Parallel degradation pathways	Lower RNA level, steady protein level
Memory To Cache	Load	By cache-line	Translation	Translation PTRO	Higher protein level, steady RNA level
	Load	Spatial locality	Translation	Parallel signaling pathways	Higher protein level, steady RNA level
	Purge	By cache-line	Protein degradation	Co-degradation (shared mechanism)	Lower protein level, steady RNA level
	Purge	Temporal locality	Protein degradation	Parallel degradation pathways	Lower protein level, steady RNA level