Figure 2. Effects of intra-VTA picrotoxin on cocaine self-administration.
(A, B) Histological reconstruction showing cannulae tip placement for 34 (A) and 68 (B) ng picrotoxin. Numbers indicate coordinates relative to bregma (Paxinos & Watson, 1998). (C) Baseline dose-response functions demonstrating cocaine self-administration on days before and after intra-VTA picrotoxin injections. (D) Dose-response functions demonstrating cocaine self-administration baseline and cocaine self-administration following bilateral intra-VTA injection of two doses of picrotoxin.