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. Author manuscript; available in PMC: 2009 Feb 6.
Published in final edited form as: Neurochem Res. 2007 Oct 17;33(3):459–467. doi: 10.1007/s11064-007-9454-2

Figure 5. Effects of picrotoxin and a high dose of 2-hydroxysaclofen co-injected into the VTA on cocaine self-administration.

Figure 5

(A) Histological reconstruction showing cannulae tip placement for co-injection of picrotoxin (68 ng) and 2-hydroxysaclofen (2 µg). Numbers indicate coordinates relative to bregma (Paxinos & Watson, 1998). (B) Baseline dose-response functions demonstrating cocaine self-administration on days before and after intra-VTA picrotoxin/2-hydroxysaclofen. Note the depressed baselines following co-injection of this combination of doses. (C) Dose-response functions demonstrating cocaine self-administration baseline and cocaine self-administration following bilateral intra-VTA co-injection of picrotoxin and 2-hydroxysaclofen.