Skip to main content
. Author manuscript; available in PMC: 2009 Feb 6.
Published in final edited form as: Neurochem Res. 2007 Oct 17;33(3):459–467. doi: 10.1007/s11064-007-9454-2

Figure 6. Effects of picrotoxin and a low dose of 2-hydroxysaclofen co-injected into the VTA on cocaine self-administration.

Figure 6

(A) Histological reconstruction showing cannulae tip placement for co-injection of picrotoxin (68 ng) and 2-hydroxysaclofen (100 ng). Numbers indicate coordinates relative to bregma (Paxinos & Watson, 1998). (B) Baseline dose-response functions demonstrating cocaine self-administration on days before and after intra-VTA picrotoxin/2-hydroxysaclofen. (C) Dose-response functions demonstrating cocaine self-administration baseline and cocaine self-administration following bilateral intra-VTA co-injection of picrotoxin and 2-hydroxysaclofen. (D) Data from animals injected with 68 ng picrotoxin alone (also shown in Figure 2D) superimposed on data from animals co-injected with 68 ng picrotoxin and 100 ng 2- hydroxysaclofen (also shown in Panel C, this figure).