Table 4.
Metabolic Syndrome and Risk of AF: Multivariable Models*
| Variables | HR (95% CI) | P |
|---|---|---|
| Metabolic syndrome | ||
| NCEP-ATPIII | ||
| All subjects | 1.88 (1.40–2.52) | <0.001 |
| Subjects without treated hypertension or diabetes> | 1.78 (1.07–2.96) | 0.03 |
| AHA/NHLBI | ||
| All subjects | 1.61 (1.21–2.15) | 0.001 |
| Subjects without treated hypertension or diabetes | 1.28 (0.78–2.1) | 0.33 |
| Metabolic syndrome components | ||
| Obesity | 1.64 (1.26–2.15) | <.001 |
| Elevated blood pressure | 1.69 (1.26–2.27) | <0.001 |
| Low HDL cholesterol | 1.52 (1.09–2.14) | 0.01 |
| Elevated triglycerides | 1.13 (0.81–1.57) | 0.47 |
| Impaired glucose tolerance (NCEP-ATPIII) | 1.44 (1.09–1.90) | 0.01 |
| Impaired glucose tolerance (AHA/NHLBI) | 1.35 (1.06–1.73) | 0.01 |
| Metabolic syndrome components, n | ||
| NCEP-ATPIII | ||
| 0 | 1.00 | |
| 1 | 1.95 (1.30–2.93) | 0.001 |
| 2 | 2.05 (1.34–3.15) | 0.001 |
| ≥3 | 3.27 (2.10–5.10) | <0.001 |
| Trend across number of components | 1.38 (1.21–1.56) | <0.001† |
| AHA/NHLBI | ||
| 0 | 1.00 | |
| 1 | 2.33 (1.47–3.72) | <0.001 |
| 2 | 2.54 (1.59–4.07) | <0.001 |
| ≥3 | 3.39 (2.08–5.53) | <0.001 |
| Trend across number of components | 1.35 (1.19–1.53) | <0.001† |
HR indicates hazard ratio.
Models were adjusted for age and gender.
Probability value was calculated from a test for trend in 4 groups based on number of fulfilled components.