Table 1.
Summary of binding kinetics
Construct | Photobleached region | t50 ± s.d. (seconds) | t90 ± s.d. (seconds) |
---|---|---|---|
Mecp2e1 | HC | 20.8±5.6 | 168.8±18.4 |
WT mouse | HC | 21.3±5.4 | 169.0±21.8 |
WT mouse | EU | 0.13±0.003 | 1.13±0.03 |
ΔN | HC | 17.6±9.3 | 143.6±21.6 |
ΔMBD | NP | 1.3±0.4 | 11.3±3.3 |
ΔID | HC | 5.3±2.1 | 37.2±8.7 |
ΔTRD | HC | 7.9±2.5 | 77.5±11.6 |
ΔC | HC | 23.9±7.8 | 163.5±23.4 |
WT human | HC | 23.4±8.8 | 156.2±22.0 |
R106W | NP | 1.4±0.42 | 12.3±3.2 |
R133C | HC | 12.4±4.5 | 84.0±10.4 |
F155S | NP | 1.5±0.5 | 13.7±4.7 |
T158M | NP | 1.4±0.3 | 12.8±2.7 |
R168X | HC | 1.2±0.5 | 8.4±2.7 |
t50 and t90 values of domain deletion and RTT mutants. HC, heterochromatin; EU, euchromatin; NP, nucleoplasm.