Table 1.

Polysomnographic Diagnostic and CPAP Titration Findings Before and After Treatment With Acetazolamide

PSG parameter	Testing conditions
	Initial diagnostic PSGa	Initial CPAP titration	Optimal CPAP+ acetazolamideb	Follow-upc
Obstructive AHI, no./h	27	12	0	0
CAI, no./h	7	66	1	17
Total AHI	34	78	1	17
RERA index, no./h	7	0	4	0
RDI, no./h	41	78	5	17
Percentage of sleep time with SaO2 less than
90%	88	57	0	0.1
85%	5	6	0	0
Mean SaO2, %	88	89	94	94
Lowest O2 value, %	78	74	93	82
AI, no./hd	18	0	1	0

^aDuration of baseline polysomnography (PSG) was 140 minutes.

^bOptimal continuous positive airway pressure (CPAP), 9 cm h₂o, and acetazolamide, 250 mg, at bedtime for 7 days.

^cFive-month follow-up on CPAP without acetazolamide (off acetazolamide for 7 days).

^dNumber of arousals per hour of sleep not related to respiratory events.

Abbreviations: AHI, apnea-hypopnea index; CAI, central apnea index; RERA, respiratory event-related arousals; RDI, respiratory disturbance index.