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Effect of 17-ODYA and miconazole on CYP activity in normal and tumor samples. The brain tissue samples from the rats infused by implanted minipumps containing vehicle control, 17-ODYA (0.3 mmol/L) or miconazole (0.3 mmol/L) were removed and assayed for CYP activity by LC-MS as described in the methods section. There was no significant difference between the levels of CYP metabolites in control and treated tumor brain tissues.
