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. Author manuscript; available in PMC: 2009 Dec 1.
Published in final edited form as: Dev Cell. 2008 Dec;15(6):813–828. doi: 10.1016/j.devcel.2008.09.003

Figure 7. Model of the Function of MenaINV Downstream of EGF Signaling.

Figure 7

In unstimulated cells, actin filaments are capped. EGF stimulation leads to PLCγ-mediated release and activation of cofilin from PIP2. Cofilin severs capped actin filaments and MenaINV binds newly generated free barbed ends. Actin filament elongation and the resulting membrane protrusion are supported by the recruitment of polymerization-competent monomers through profilin binding and the anticapping activity of Mena. Subsequently, the Arp2/3 nucleates new filaments that branch off the growing filaments.