Table 2.
Electrophysiological proprieties of mPFC pyramidal neurons
| RS1 (10) | RS2 (15) | NIB (14) | dNIB (9) | |
| Firing ratea, silent | 0.3 ± 0.1 | 1 ± 0.3 | 2 ± 0.3 | See NIB |
| 10% | 47% | 18% | ||
| % Burst | NA | NA | 60 ± 5.8 | See NIB |
| RMP/Vdownb | –68 ± 2.9 | –74 ± 3.2 | –77 ± 1.5* | –66 ± 1.2* |
| Vthreshold/Vup statb | –61 ± 2.9 | –68 ± 3.2 | –57 ± 1.3 | –56 ± 1.8 |
| Coefficient of variationc | 0.3 ± 0.02 | 0.4 ± 0.02 | NA | NA |
| APamplb | 65 ± 2.4 | 60 ± 2.2 | 62 ± 1.7 | See NIB |
| AP1/2widthd | 0.9 ± 0.08 | 1 ± 0.1 | 1 ± 0.1 | See NIB |
| τd | 11 ± 2.4 | 10 ± 1.4 | 9 ± 0.8 | See NIB |
| Rie | 40 ± 1.6 | 42 ± 3 MΩ | 41 ± 2.6 MΩ | See NIB |
| Rectification | 25% | 40% | 28% | |
| No-rectification | 75% | 60% | 72% | See NIB |
Note: All data are expressed as mean ± SEM. *Statistically different: Vdown of NIB versus Vdown of dNIB. One-way ANOVA; DF = [1,20], F ratio = 26.5, P < 0.01
a
Firing rate is measured in Hz.
b
Resting membrane potential (RS neurons), membrane voltage of down state (NIB neurons), membrane voltage at threshold (RS) or membrane voltage of up state (NIB) as well as action potential amplitude are all measured in mV.
c
Coefficient of variation of membrane voltage, measured as SEM/mean of RMP.
d
Action potential amplitude calculated at half width and membrane time constant (τ) calculated at 63% plateau are expressed in ms.
e
Input resistance (Ri) expressed in MΩ.