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. 2008 Jul 16;19(3):658–674. doi: 10.1093/cercor/bhn114

Table 3.

Effects of EC stimulation on RS2 and NIB pyramidal neurons

VupVdwn Area Duration % Time # Events/min Frequency
RS2 baseline 6 ± 0.5 1702 ± 204.6 459 ± 47.5 33 ± 5.8 43.5 ± 6.9 0.7 ± 0.1
0.1 mA 8.3 ± 1.5 3352 ± 557.6* 843.3 ± 106* 44.8 ± 8.4 31.7 ± 5.3 0.5 ± 0.09
0.5 mA 9 ± 1.3* 3486 ± 330.7* 817 ± 67.6* 49.8 ± 7.4 39.2 ± 6.8 0.6 ± 0.1
1 mA 11 ± 1.5* 6917 ± 1610.3* 1568 ± 352.4* 69 ± 1.9* 34.4 ± 8.4 0.6 ± 0.1
dNIB baseline 10 ± 1+ 3393 ± 514.5+ 653 ± 71.9 53 ± 3 55 ± 3.5 0.9 ± 0.06
1 mA 10.5 ± 1.6 7049 ± 2132.7** 1389 ± 437.3** 64 ± 2.5** 36 ±6.5** 0.6 ± 0.1**
NIB baseline 20 ± 1.4+ 6412.3 ± 562.7+ 768.8 ± 38.3 65.1 ± 2.8 48.5 ± 1.5 0.8 ± 0.01
1 mA 19.4 ± 1.8 7691.1 ± 1499.1 1006.3 ± 111.6 66 ± 4.5 46.8 ± 3 0.8 ± 0.05

Note: *Statistically different from baseline. Baseline versus 0.1 mA stimulus: Area (one-way ANOVA; DF = [1, 16], F ratio = 11.7, P = 0.03); duration (one-way ANOVA; DF = [1, 16], F ratio = 14.9, P = 0.01). Baseline versus 0.5 mA stimulus: VupVdwn (Kruskal–Wallis one-way ANOVA on Ranks test; diff. of ranks = 5.6, Q = 2.2, P < 0.05); area (DF = [1, 18]; F ratio = 23.6; P < 0.001); duration (one-way ANOVA; DF = [1, 18]; F ratio = 20; P < 0.001). Baseline versus 1 mA stimulus: VupVdwn (one-way ANOVA; DF = [1, 14], F ratio = 14.7, P = 0.02); Area (Kruskal–Wallis one-way ANOVA on Ranks test; diff. of ranks = 8.5, Q = 3.2, P < 0.05); duration (Kruskal–Wallis one-way ANOVA on Ranks test; diff. of ranks = 7.9, Q = 2.9, P < 0.05); % time (Kruskal–Wallis one-way ANOVA on Ranks test; diff. of ranks = 7.6, Q = 2.8, P < 0.05).

**

Statistically different from baseline. Baseline versus 1 mA stimulus: Area (DF = [1, 11]; F ratio = 5.5; P < 0.05); Duration (Fig. 8B,C) (DF = [1, 10]; F ratio = 5.6; P < 0.05); % Time (DF = [1, 11]; F ratio = 5.2; P < 0.05); # Events/min (DF = [1, 11]; F ratio = 7.7; P < 0.05); Frequency (DF = [1, 11]; F ratio = 7.7; P < 0.05).

+

Statistically different: baseline of dNIB versus baseline of NIB. VupVdwn (one-way ANOVA; DF = [1, 20]; F ratio = 25.8; P < 0.001); Area (one-way ANOVA; DF = [1, 21]; F ratio = 13.7; P = 0.001). None of the parameters of the NIB neurons were significantly altered by EC stimulation (pre versus poststimulus, one-way ANOVA; P > 0.05).

In all PSTHs, the dotted line indicates delivery of the stimulus pulse.