Skip to main content
. 2009 Jan 16;10(2):137–143. doi: 10.1038/embor.2008.242

Figure 2.

Figure 2

Mouse models of mitochondrial DNA and its maintenance. (A) Main tissue manifestations of mtDNA disease models. (B) Crucial tissue manifestations of mice lacking mtDNA maintenance proteins. Mice in which mtDNA replication proteins are absent die during embryonic development, whereas those without proteins involved in maintaining the nucleotide pools present postnatal symptoms. (C) Various tissue manifestations of prematurely aged Mutator mice. ΔmtDNA, Mito-mice with single mtDNA deletion; ANT1, adenine nucleotide translocator; HSP40, heat-shock protein 40 mitochondrial chaperone; MPV17, mitochondrial inner membrane protein; mtDNA, mitochondrial DNA; NRF1, nuclear respiratory factor 1; p53R2, ribonucleotide reductase subunit; POLG, DNA polymerase γ; PstI, restriction endonuclease; RNaseH, ribonuclease H1; TFAM, mitochondrial transcription factor A; TK2, thymidine kinase 2.