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. 2009 Jan 15;28(3):274–285. doi: 10.1038/emboj.2008.278

Figure 5.

Figure 5

Structural basis for inhibiting eIF4A by Pdcd4. (A) Stereo view showing the superposition of eIF4AIII (in the EJC; grey) and Pdcd4-bound eIF4A (eIF4A-A; green). RNA is shown in magenta, ATP in ball-and-stick model and nMA3 of Pdcd4 in salmon. The view of eIF4A-A is as in Figure 1C. (B) Ribbon diagram showing the open nonproductive conformation of Pdcd4-bound eIF4A. Motifs Q, I, Ia, Ib, GG, II and III in the NTD are shown in orange whereas motifs IV, V, VI in the CTD are shown in blue. The view is as in (A). (C) Ribbon diagram of the close active conformation of eIF4AIII with bound RNA and ATP in the EJC. The colouring scheme for the motifs is as in (B). and the view is as in (A). (D) A close-up view in stereo showing the conformational difference of P loop in Pdcd4-bound eIF4A and eIF4AIII in EJC.