Skip to main content
. Author manuscript; available in PMC: 2010 Jan 14.
Published in final edited form as: Eur J Pharmacol. 2008 Dec 3;602(2-3):223–229. doi: 10.1016/j.ejphar.2008.11.044

Fig. 3. The acridine-based compounds intercalate into DNA.

Fig. 3

The DNA unwinding reaction mixtures contained 0.3 μg of relaxed plasmid DNA, 2 units of human topoisomerase I, and 100 μM of the various drugs. Two independent experiments for each assay exhibited essentially identical results; representative results are shown. Drugs are denoted as follows: 1, compound 1; 2, compound 2; 3, compound 3; 4, compound 4; A, amsacrine; and E, etoposide.