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. Author manuscript; available in PMC: 2010 Jan 14.
Published in final edited form as: Eur J Pharmacol. 2008 Dec 3;602(2-3):223–229. doi: 10.1016/j.ejphar.2008.11.044

Fig. 5. The acridine-based compounds inhibit the catalytic activity of human topoisomerase II.

Fig. 5

Fig. 5

The DNA unwinding assay for human topoisomerase I (Panel A) and the strand passage assay for human topoisomerase II (Panel B) were performed in the presence of indicated concentrations of the acridine-based compounds. Three independent experiments for each assay exhibited essentially identical results; representative results are shown. Abbreviations are as indicated in the legend to Fig. 3.