Table 3.

The Neuroprotective Effect of Compound C in Wild-Type Mice After MCAO (24- or 72-hour survival)

	Cortical (%)	Striatal (%)	Total (%)	Scores
24-hour survival
Control (n=7)	36.8±3.2	48.0±4.9	41.3±4.5	2.6±0.21
Compound C (n=7)	18.1±4.1*	30.0±5.6*	22.4±3.9*	1.9±0.24*
72-hour survival
Control (n=6)	54.1±3.6	73.6±7.8	61.7±3.6	3.0±0.4
Compound C (n=8)	31.8±2.1*	49.4±3.0	38.3±2.3*	1.7±0.1*

Mice were treated intraperitoneally with 20 mg/kg per body weight of Compound C or vehicle at the onset of the stroke. Cortical, striatal, and total infarct volumes were measured (shown as percentage of the nonischemic hemisphere). Mean±SEM.

^*P<0.05, one-way analysis of variance, compared with corresponding vehicle-treated mice control. The neurological deficit scores were analyzed by Mann–Whitney U test.