Table 5.
Comparison of Parimon and present study data
| Variable | Parimon 2006 | Present study | |||||
|---|---|---|---|---|---|---|---|
| no (%) | Score | no (%) | Univariable β (se) for OS | Multivariable β (se) for OS | Univariable β (se) for NRM | Multivariable β (se) for NRM | |
| No. patients | 2802 | 286 | |||||
| Age, y | |||||||
| <15 | 1 (0) | NC | 57 (20) | −0.01 (0.30) | 0.31 (0.31) | 0.17 (0.35) | 0.41 (0.38) |
| 15–50 | 2158 (77) | 1 | 172 (60) | 0 | 0 | 0 | 0 |
| 50–60 | 545 (19) | 3 | 52 (18) | 0.32 (0.27) | 0.61 (0.33) | 0.45 (0.33) | 0.54 (0.41) |
| >60 | 98 (4) | 5 | 5 (2) | −0.24 (1.01) | −0.16 (1.17) | NC* | NC* |
| Donor type | |||||||
| Related, matched | 1354 (48) | 1 | 149 (52) | 0 | 0 | 0 | 0 |
| Unrelated | 1161 (42) | 3 | 129 (45) | 0.87 (0.23) | 0.86 (0.24) | 0.96 (0.29) | 1.02 (0.31) |
| Related, mismatched | 285 (10) | 4 | 8 (3) | −0.05 (0.73) | −0.35 (0.74) | NC* | NC* |
| Disease risk | |||||||
| Low | 781 (28) | 1 | 38 (13) | 0 | 0 | 0 | 0 |
| Intermediate | 787 (28) | 8 | 156 (55) | 0.83 (0.43) | 0.55 (0.48) | 0.28 (0.45) | −0.02 (0.52) |
| High | 1234 (44) | 12 | 92 (32) | 0.65 (0.45) | 0.57 (0.53) | 0.45 (0.47) | 0.19 (0.56) |
| Conditioning regimen | |||||||
| Nonmyeloablative | 174 (6) | 1 | 114 (40) | 0 | 0 | 0 | 0 |
| Non-total-body-irradiation | 927 (33) | 4 | 108 (38) | −0.09 (0.26) | 0.28 (0.37) | −0.34 (0.32) | 0.05 (0.45) |
| TBI with ≤ 12 Gy | 726 (26) | 8 | 64 (22) | 0.25 (0.28) | 0.44 (0.42) | −0.08 (0.36) | 0.37 (0.52) |
| TBI with > 12 Gy | 975 (35) | 9 | 0 (0) | NC* | NC* | NC* | NC* |
| Serum creatinine level | |||||||
| ≤ 1.2 mg/dL | 2531 (90) | 1 | 281 (98) | 0 | 0 | 0 | 0 |
| > 1.2 mg/dL | 271 (10) | 8 | 5 (2) | 0.34 (0.72) | 0.46 (0.81) | 0.80 (0.72) | 1.23 (0.75) |
| Serum alanine aminotransferase level | |||||||
| ≤ 49 U/L | 2210 (79) | 1 | 176 (62) | 0 | 0 | 0 | 0 |
| > 49 U/L | 592 (21) | 2 | 110 (38) | −0.18 (0.23) | −0.23 (0.23) | −0.23 (0.29) | −0.22 (0.29) |
| FEV1 | |||||||
| > 80% | 2293 (82) | 1 | 86/97 (89) | 0 | NC* | 0 | NC* |
| 70%–80% | 321 (11) | 3 | 6/97 (6) | 1.37 (0.63) | NC* | 1.77 (0.65) | NC* |
| ≤ 70% | 188 (7) | 6 | 5/97 (5) | −0.02 (1.03) | NC* | 0.41 (1.05) | NC* |
| DLCO | |||||||
| ≥ 70% | 2624 (94) | 1 | 34/82 (41) | 0 | NC* | 0 | NC* |
| < 70% | 178 (6) | 4 | 48/82 (59) | 0.15 (0.49) | NC* | 0.31 (0.63) | NC* |
*
NC: not calculated because insufficient event number or data
Comparison of original PAM scores and 10 times β coefficient in our cohort allows to apprehend the discriminative value of each item in our cohort