Table 1.

NZB loci linked with nephritis

Marker*	Position*	(B6.H2z × NZB)F1 × NZB		(BALB.H2z × NZB)F1 × NZB		Both crosses
		P value	OR	P value	OR	P value	OR
		All mice (n = 134)		All mice (n = 158)		All mice (n = 292)
D1Mit111	1, 91	0.16	1.79	0.48	1.40	0.13	1.61
Crp/Sap	1, 94	1.0 × 10−3†	4.58	0.071	2.17	3.3 × 10−4†	3.09
D1Mit206	1, 96	3.0 × 10−3†	4.50	NT	NT	NA	NA
D4Mit9	4, 43	0.17	1.07	2.2 × 10−3†	3.65	0.020	2.01
D4Mit58/D4Mit28	4, 50	0.23	1.67	2.9 × 10−3†	3.42	2.6 × 10−3†	2.44
D4Mit70	4, 65	0.71	1.17	0.020	2.51	0.052	1.74
D11Mit84/D11Mit2	11, 17/11, 9	0.63	1.24	0.011	2.90	0.026	1.96
D14Mit41/D14Mit34	14, 43/14, 40	0.097	2.05	0.044	2.26	8.8 × 10−3	2.16
H2§	17, 19	4.4 × 10−4†	5.56	0.55	1.28	4.0 × 10−3	2.44
		H2z-positive (n = 74)		H2z-positive (n = 90)		H2z-positive (n = 164)
D1Mit111	1, 91	0.012	3.56	0.15	2.39	2.9 × 10−3†	3.11
Crp/Sap	1, 94	3.0 × 10−4†	7.29	5.5 × 10−3	4.48	2.6 × 10−6‡	5.97
D1Mit206	1, 96	8.4 × 10−4†	7.13	NT	NT	NA	NA
D4Mit9	4, 43	0.99	1.00	0.045	2.88	0.14	1.71
D4Mit58/D4Mit28	4, 50	0.17	2.02	0.051	2.74	0.015	2.40
D4Mit70	4, 65	0.68	1.13	0.096	2.34	0.12	1.74
D11Mit84/D11Mit2	11, 17/11, 9	0.87	0.92	2.4 × 10−3†	5.02	0.022	2.31
D14Mit41/D14Mit34	14, 43/14, 40	0.45	1.47	2.9 × 10−3†	4.69	4.8 × 10−3	2.76

Mice were classified as positive for nephritis if proteinuria was detected at ≥100 mg/dl on two or more successive occasions, or ≥100 mg/dl proteinuria at the testing immediately prior to death. Mice which never exhibited proteinuria at ≥100 mg/dl were classified as negative for nephritis. The percentages of mice developing nephritis in each backcross are shown in Fig. 1. NT, not tested; NA, not applicable. 

^*Markers and their respective positions are presented. For some chromosomal positions, it was necessary to use different markers for the two backcrosses because of the absence of polymorphism with NZB. This is indicated by the presence of two marker names separated by a slash. In these cases the marker used for the (B6.H2^z × NZB)F₁ × NZB backcross is presented to the left of the slash, and the marker used for the (BALB.H2^z × NZB)F₁ × NZB backcross is presented to the right of the slash. 

^†Loci showing suggestive linkage with nephritis (χ² > 8.58; P < 0.0034). 

^‡Loci showing probable linkage with nephritis (χ² > 15.13; P < 0.0001). 

^§The disease susceptibility allele for this locus, H2^z, is contributed by the B6.H2^z or BALB.H2^z strain. The inverse of the odds ratio is presented for this locus for ease of comparison with all other loci, for which the disease susceptibility allele is contributed by the NZB mouse.