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. Author manuscript; available in PMC: 2009 Dec 1.
Published in final edited form as: Cell Metab. 2008 Dec;8(6):459–467. doi: 10.1016/j.cmet.2008.10.004

Figure 2. Bidirectional molecular targeting of MBH S6K activity is sufficient to alter food intake and body weight.

Figure 2

(A) changes in body weight and (B) changes in food intake after MBH injection of CA S6K (n=12, filled triangle), DN S6K (n=13, filled square) or LACZ (n=18, open circle). (C) MBH NPY mRNA, (D) MBH AgRP mRNA and (E) MBH POMC mRNA levels normalized to that of actin in CA S6K, DN S6K, LACZ and LACZ pairfed controls (n=6–8). Cumulative food intake over 9 days is 231.7 ± 9.4, 275.27 ± 6.65 and 269.1 ± 7.4 in CA S6K, DN S6K and LACZ controls, respectively. All data are means ± SEM.