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. Author manuscript; available in PMC: 2009 Dec 1.
Published in final edited form as: J Immunol. 2008 Dec 1;181(11):8027–8035. doi: 10.4049/jimmunol.181.11.8027

Figure 3. Hepatic expression of COX-2 enhances serum transaminase levels induced by LPS.

Figure 3

The COX-2 transgenic mice and the age/sex-matched wild type mice were administered intraperitoneally 30 ng/g body weight of LPS in combination with 800 μg/g body weight of D-galactosamine (D-GalN). The animals were sacrificed 4 hours after injection. Blood samples were collected and sera were separated for transaminase analysis. The COX-2 transgenic mice show significantly higher serum ALT and AST levels than the wild type mice after LPS/D-GalN treatment (p<0.01 compared to wild type mice treated with LPS/D-GalN) (similar transaminase levels were observed between COX-2 transgenic and wild type mice when the animals were not subjected to LPS/D-GalN treatment).