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. Author manuscript; available in PMC: 2009 Nov 1.
Published in final edited form as: Virus Res. 2008 Aug 23;137(2):198–205. doi: 10.1016/j.virusres.2008.07.010

Figure 2. Infection with a high or lethal dose of VACV-Ova resulted in increased apoptosis in naïve and activated CD8+ T cells in the spleen.

Figure 2

C57BL/6 mice were infected i.n. with low (5×102), high (5×104), or lethal (5×105) dose of VACV-Ova or were mock-infected (PBS) and spleens harvested at day 7. A) Representative flow cytometric data showing active caspase 3 staining of CD44lo and CD44hi cells following gating on CD8+ T cells. Numbers above the dot plot are the percentage of cells in each quadrant. The numbers in the quadrants are the percentage of CD44lo (upper left) or active CD44hi (upper right) cells that are active caspase 3+ positive. B) Averaged data showing the percent of CD44lo or CD44hi CD8+ T cells staining positive for active caspase 3. * = significant increase, p<0.05; # = significant decrease, p<0.05.