C57BL/6 mice were infected i.n. with the low (squares), high (triangles), or lethal (diamonds) dose of VACV-Ova or were mock-infected (circles). The level of inflammatory cytokines (IL-12p70, TNFα, IFNγ, MCP-1, and IL-16) in the plasma at the indicated timepoints was determined by CBA (see Materials and Methods). Each data point represents 5 mice ± SEM. * = p < 0.05 compared to low dose-infected mice.