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. Author manuscript; available in PMC: 2009 Mar 18.
Published in final edited form as: Nature. 2008 Aug 24;455(7211):401–405. doi: 10.1038/nature07213

Table 1.

PluriNet Expression patterns in various model system for pluripotecy

A: Expression of PluriNet genes
in murine model systems
MII Oocytes up-regulateda
Zygote up-regulateda
Embryo (2 cell–Blastocyst) up-regulateda
ePSC up-regulatedb
EpiSC up-regulatedb
iPSC up-regulatedb
Fibroblasts (normal) down-regulatedb
Fibroblasts (transformed) down-regulatedb
B: Successful PluriNet based, post-hoc classification for …
in murine model systems pluripotency germ-line transmission
ePSC yesc yesc
EpiSC yesc yesc
iPSC yesc yesc
Fibroblasts (normal) yesc yesc
Fibroblasts (transformed) yesc yesc
C: Expression of PluriNet genes
in human model systems
MII Oocytes up-regulatedd
tPSC up-regulatede
ePSC up-regulatede/f
iPSC up-regulatede/f
ePSC derived cell types down-regulatedf
somatic cell types down-regulatede/f
somatic cancer line (HeLa) down-regulatedg
D: Successful PluriNet based, post-hoc classification for …
in human model systems pluripotency
tPSC yesh
ePSC yesh
iPSC yesh
ePSC derived cell types yesh
somatic cell types yesh

graphic file with name nihms81942u1.jpg

a

for more details see Supplementary Figure 8

b

for more details see Supplementary Figures 9 and 10

c

for more details see Supplementary Figure 10

d

for more details see Supplementary Figure 7

e

for more details see Figure 3B, Supplementary Figures 5 and 12

f

for more details see Supplementary Figure 11

g

for more details see Supplementary Discussion 2 PluriNet and Cell Cycle

h

for more details see Supplementary Figure 12

PAM – Prediction Analysis of Microarray classifier with leave-one-out cross validation27;

“yes” in Table 3B and 3D stands for: correct classification of pluripotent state (pluripotent or not pluripotent) in > 90% of samples.

This table summarizes the expression patterns of PluriNet in various model systems of pluripotence and differentiation. More details on the specific tests and explanations of the data sources for the results can be found at the respective Supplementary Figures and Materials as listed in the above.