TABLE 2.

Effect of ventral subiculum lesion on physiological responses to chronic variable stress

	Handled		Stressed
	Saline	Ibotenate	Saline	Ibotenate
Body Weight Change (gm)	63.8 ± 10.9	62.5 ± 4.1	16.3 ± 4.4*	19.8 ± 5.5*
Thymus Weight (mg/gm BW × 100)	93.3 ± 5.5	84.1 ± 4.0	66.5 ± 6.6*	62.6 ± 5.0*
Adrenal Weight (mg/gm BW × 100)	11.1 ± 0.4	10.2 ± 0.6	15.4 ± 0.7*	14.8 ± 0.6*
PVN CRH mRNA** (corrected gray level)	73.8 ± 1.4	86.5 ± 3.0	87.6 ± 4.4	78.6 ± 2.6

Chronic variable stress significantly decreased body weight gain and thymus size and increased adrenal size. Ibotenate lesions of the vSUB did not alter any of the physiological variables in the handled animals nor did ibotenate lesions affect the response to chronic variable stress.

^**There was a significant interaction between ibotenate lesion and chronic variable stress on CRH mRNA levels in the PVN. BW, body weight.

^*P < 0,05 versus corresponding handled control.