Total neurological score, which incorporates postural reflex and forelimb-placing tests (normal score=0, maximal score=12) during MCAo and at various times after treatment. At 60 min of MCAo, all animals had a score of 11 (of a possible 12). LAU-0901 (n=12) or vehicle (n=11) treatment was administered at 2 h after onset of ischemia. LAU-0901-treated rats had a significantly improved neurological score, compared to the corresponding vehicle group, throughout the 30-day survival period. Values shown are means ± SEM., *P<0.05, LAU-0901 vs. vehicle.