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. Author manuscript; available in PMC: 2009 Feb 9.
Published in final edited form as: Chem Biol Drug Des. 2008 Jul 15;72(2):140–146. doi: 10.1111/j.1747-0285.2008.00685.x

Figure 2.

Figure 2

Residues identified that exhibit chemical shift changes as monitored in Figure 1A with increasing signal peptide concentration (50–1000 µm) as indicated in the legend. Major changes were observed only in the proton dimension as shown. The shift of a peak at each signal peptide concentration was compared to the peak measured without addition of the signal peptide. Changes of residues proposed to be critical to the proteolytic mechanism are shaded by a gray box. For comparison, Leu96 that did not shift is also shown.