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. Author manuscript; available in PMC: 2009 Oct 1.
Published in final edited form as: Clin Immunol. 2008 Jul 26;129(1):115–122. doi: 10.1016/j.clim.2008.06.008

Figure 2. Clinical index of disease activity is increased in animals deficient in GRK6 and -2, but not -5, compared to wildtype controls.

Figure 2

Figure 2

Shown is the mean clinical index ± SEM over time in days as determined by the summation of each paw scored on a scale of 0–3 and averaged for the group. The data are combined from 3 (GRK6−/−) and 2 (GRK2+/− and GRK5−/−) separate experiments. A. GRK6−/− mice have the most disease severity that is more pronounced earlier in the disease course (LRT=19, 3 df, p<0.0003; GRK6−/− n=14, WT n=13). B. GRK2 +/− mice also show enhanced disease (LRT=18.9, 3 df, p=0.0003; GRK2+/− n=12, WT n=13). C. GRK5−/− mice do not differ from wildtype controls (LRT=6.1,df=3, p=0.1068; GRK5−/− n=11, WT n=13).