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Schematic representation of endothelial nitric oxide synthase (eNOS) uncoupling. During uncoupling, biosynthesis of nitric oxide (NO) is uncoupled from consumption of NADPH and electron flow is directed towards formation of superoxide anion (O2.−) and hydrogen peroxide (H2O2). Subsequent reaction between superoxide anion and NO generates peroxynitrite anion (ONOO−). Suboptimal concentrations of BH4 (↓).
