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. Author manuscript; available in PMC: 2009 Feb 9.
Published in final edited form as: Genomics. 2007 Jun 4;90(2):225–235. doi: 10.1016/j.ygeno.2007.04.006

Figure 5.

Figure 5

In-vitro functional characterization of CNSs in SH-SY5Y cells. (A) Orthologous CNSs within the SCN1A locus were cloned into a vector containing the firefly luciferase gene under the control of the SV40 promoter (pGL3 promoter). (B) Human paralogous CNSs were cloned into a vector containing the firefly luciferase gene under the control of a human SCN2A promoter. All values are normalized to the empty vector (pGL3 basic). Error bars represent the SEM, and asterisks indicate statistically significant changes in luminescence when compared to the vector containing only the promoter.