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. Author manuscript; available in PMC: 2010 Jan 1.
Published in final edited form as: Ageing Res Rev. 2008 Oct 31;8(1):43–51. doi: 10.1016/j.arr.2008.10.002

Figure 3.

Figure 3

The functional relationship of klotho and transient receptor potential vanilloid 5 (TRPV5) in kidneys. The β-glucuronidase activity plays an important role in activating TRPV5. Klotho in urine, as a β-glucuronidase, hydrolyzes the N-linked extracellular sugar residues of TRPV5, and then augments the retention of TRPV5 on the plasma membrane hence increase the influx of Ca2+ in kidneys.