Table 3.
Clinicopathologic findings in previously reported cases of MGN with ANCA-associated NCGN
| Author (ref) | Age/sex | ANCA by IIF | ANCA specificity by ELISA | Extrarenal features of vasculitis | ANA | Creatinine (mg/dl) | 24-h urine protein (g) | Albumin (g/dl) | Hematuria | % of glomeruli with crescents | MGN stage | Treatment | Length of follow-up | Outcome |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gaber (5) | 64/M | C-ANCA | NA | Recurrent sinusitis Otitis media Pulmonary capillaritis | Neg | 3.4 | 1.6 | NP | Yes | 11% | II-III | PRED/CY | 22 months | Resolution of pulmonary lesions, Normalization of s. Cr, Diminution of proteinuria |
| Taniguchi (6) | 68/F | NA | MPO | None | Neg | 1.45 | 1.26 | 3.2 | Yes | 55% | II | PRED | 3 months | Normalization of s. Cr |
| Kanahara (7) | 47/F | P-ANCA | MPO | Pulmonary hemorrhage | Neg | 1.1 | 5.7 | 2.9 | Yes | NP | III-IV | M-PRED then PRED/CY | 6 months | Diminution of proteinuria, Disappearance of crescents (on repeat Bx) |
| Dwyer (8) | 67/M | P-ANCA | MPO | None | Neg | HD | 7.16 | 2.7 | Yes | NP | II-III | PRED/ azathioprine | NP | ESRD |
| Dwyer (8) | 69/M | P-ANCA | MPO | Iritis | Pos | 1.47 | 0.56 | 2.6 | Yes | 23% | I | PRED/CY | NP | Normalization of s. Cr |
| Tse (9) | 30/M | C-ANCA | NA | Cutaneous vasculitis | Neg | 1.4 | 1.5 | 3.5 | Yes | 50%(1 of 2 glomeruli) | II | PRED/CY | 10 yr | Stable renal function |
| Tse (9) | 64/M | P-ANCA | NA | None | Neg | 5.8 | 10 | 3 | Yes | 23% | II | None | 2 yr | ESRD 3 months post-Bx |
| Tse (9) | 65/M | P-ANCA | NA | None | Neg | 1.7 | 2.4 | 3.3 | Yes | 28% | I | PRED/CY | 5 yr | Partial recovery (s. Cr 1.5 mg/dl) |
| Tse (9) | 70/M | C-ANCA | NA | Nasal obstruction Rash | Neg | 13.8 | Oliguric | 3.9 | No | 73% | II | PRED/CY/ HD/PLX | 5 yr | Partial recovery (s. Cr 2.2 mg/dl) |
| Suwabe (10) | 68/F | NA | MPO | None | Neg | 3 | 7 | 2.5 | Yes | 31% | I-II | PRED/CY | 10 months | Partial recovery |
| (s. Cr 1.8 mg/dl, 24-h urine protein 0.5 g) |
MGN, membranous glomerulonephritis; ANCA, antineutrophil cytoplasmic antibody; NCGN, necrotizing and crescentic glomerulonephritis; IIF, indirect immunofluorescence; ELISA, enzyme-linked immunosorbent assay; ANA, antinuclear antibody; Bx, biopsy; CY, cyclophosphamide; HD, hemodialysis; MPO, myeloperoxidase; M-PRED, pulse methyleprednisolone; NA, not available; NP, not provided; s. Cr, serum creatinine; PLX, plasmapheresis; PRED, prednisone; UA, urinalysis