Table 2.

Changes in hemoglobin and serum iron indices after ferumoxytol or oral iron therapy (ITT Population)^a

Treatment Group	Baseline	Day 21	Change at Day 21	P for Day 21 Changeb	Day 35	Change at Day 35	P for Day 35 Changeb
Hemoglobin (g/dl)
Ferumoxytol	10.59 ± 0.67	11.41 ± 1.23	0.71 ± 1.07	0.0067	11.72 ± 1.20	1.02 ± 1.13	0.0002
Oral iron	10.69 ± 0.57	11.09 ± 1.07	0.35 ± 0.90		11.22 ± 1.22	0.46 ± 1.06
TSAT (%)
Ferumoxytol	15.71 ± 7.21	22.00 ± 12.17	6.22 ± 12.12	0.0015	22.31 ± 13.33	6.44 ± 12.59	<0.0001
Oral iron	15.91 ± 6.29	17.08 ± 9.54	1.39 ± 8.88		16.46 ± 9.72	0.55 ± 8.34
Ferritin (ng/ml)
Ferumoxytol	340.52 ± 159.07	749.49 ± 301.63	356.66 ± 247.12	<0.0001	601.79 ± 282.95	233.93 ± 206.95	<0.0001
Oral iron	357.56 ± 171.65	316.24 ± 173.51	−37.56 ± 106.98		289.30 ± 165.76	−59.23 ± 106.22
Serum iron (μg/dl)
Ferumoxytol	49.49 ± 20.20	60.06 ± 31.54	10.84 ± 31.40	0.1328	58.64 ± 27.88	9.20 ± 27.77	0.0557
Oral iron	48.23 ± 18.73	53.07 ± 24.78	4.87 ± 23.33		51.02 ± 26.28	2.61 ± 21.71
TIBC (μg/dl)
Ferumoxytol	322.36 ± 76.78	280.26 ± 67.83	−41.25 ± 57.02	<0.0001	275.67 ± 60.71	−45.88 ± 52.53	<0.0001
Oral iron	313.89 ± 65.84	310.67 ± 65.86	−4.16 ± 46.87		319.62 ± 67.29	4.21 ± 50.26
CHr (pg)
Ferumoxytol	31.12 ± 2.62	32.42 ± 2.60	1.32 ± 1.59	<0.0001	32.22 ± 2.69	1.09 ± 1.64	<0.0001
Oral iron	31.57 ± 2.48	31.68 ± 2.42	0.07 ± 1.46		31.56 ± 2.39	0.00 ± 1.46

^aMean ± SD data are presented.

^bTwo-sample t-tests evaluated treatment differences in changes from baseline.

TIBC, total iron binding capacity; CHr, reticulocyte hemoglobin content; TSAT, transferrin saturation.