Table 1.
Patient and transplant characteristics of the study cohort (N = 314)
| Factor | Number (%) |
|---|---|
| Baseline characteristics | |
| age in years (median & range) | 42.7 (0.6 to 67.8) |
| diagnosis | |
| hematologic malignancies | 160 (51%) |
| myelodysplastic syndrome | 48 (15%) |
| lymphoma | 43 (14%) |
| multiple myeloma | 28 (9%) |
| aplastic anemia | 11 (3.5%) |
| other | 24 (7.5%) |
| patient/donor gender | |
| male/male | 129 (41) |
| male/female | 62 (20) |
| female/female | 75 (24) |
| female/male | 48 (15) |
| Donor type | |
| related-matched | 106 (34) |
| related-mismatched | 44 (14) |
| unrelated | 115 (37) |
| autologous/id twin | 49 (15) |
| TBI conditioning (cGy) | |
| none | 115 (37) |
| ≤ 1200 | 78 (25) |
| > 1200 | 121 (38) |
| Post-transplant features | |
| acute GVHD grade | |
| 0, I | 58 (18) |
| II | 55 (18) |
| III | 85 (27) |
| IV | 61 (19) |
| autologous/syngeneic | 49 (16) |
| missing | 6 (2) |
| incidence of infection | |
| adenovirus | 52 (17) |
| cytomegalovirus | 63 (20) |
| herpes simplex virus | 58 (18) |
| varicella virus | 11 (4) |
| received acyclovir | 246 (81) |
| received amphotericin | 209 (67) |
| Acute kidney injury 2 wk before death | 128 (41) |
| incidence of infection | |
| bacterial | 103 (33) |
| fungal | 35 (11) |
| incidence of dialysis | 82 (26) |
| incidence of intubation | 119 (38) |
| mean total serum bilirubin (mg/dl, median & range) | 4.9 (0.4 to 59.6) |
| mean serum creatinine (mg/dl, median & range) | 1.56 (0.27 to 5.79) |