Table 2.
Univariate odds ratios with 95% confidence intervals comparing each histologic type to kidneys with no evidence of thrombosis or TMA in the kidney at autopsy
| Factor | Negative (n = 203) N (%) | Isolated renal thrombosis (n = 47)
|
TMA (n = 64)
|
||
|---|---|---|---|---|---|
| N (%) | OR (95% CI) | N (%) | OR (95% CI) | ||
| Baseline characteristics | |||||
| patient/donor gender | |||||
| male/male | 86 (42) | 16 (34) | 1.0 | 27 (42) | 1.0 |
| male/ female | 44 (22) | 8 (17) | 1.0 (0.4 to 2.5) | 10 (16) | 0.7 (0.3 to 1.6) |
| female/female | 51 (25) | 13 (28) | 1.4 (0.6 to 3.1) | 11 (17) | 0.7 (0.3 to 1.5) |
| female/male | 22 (11) | 10 (21) | 2.4 (1.0 to 6.1) | 16 (25) | 2.3 (1.1 to 5.0) |
| donor type | |||||
| related-matched | 63 (31) | 21 (45) | 1.0 | 22 (34) | 1.0 |
| related-mismatched | 26 (13) | 9 (19) | 1.0 (0.4 to 2.6) | 9 (14) | 1.0 (0.4 to 2.4) |
| unrelated | 70 (34) | 14 (30) | 0.6 (0.3 to 1.3) | 31 (48) | 1.3 (0.7 to 2.4) |
| autologous/id twin | 44 (22) | 3 (6) | 0.2 (0.1 to 0.7) | 2 (3) | 0.1 (0.03 to 0.6) |
| TBI conditioning (cGy) | |||||
| none | 84 (41) | 16 (34) | 1.0 | 15 (23) | 1.0 |
| 200 to 1200 | 53 (26) | 9 (19) | 0.9 (0.4 to 2.2) | 16 (25) | 1.7 (0.8 to 3.7) |
| 1240 to 1350 | 54 (27) | 13 (28) | 1.3 (0.6 to 2.8) | 27 (42) | 2.8 (1.4 to 5.7) |
| > 1350 | 12 (6) | 9 (19) | 3.9 (1.4 to 10.9) | 6 (9) | 2.8 (0.9 to 8.6) |
| Median (range) | Median (range) | Median (range) | |||
| agea | 43.1 (0.6 to 67.1) | 46.4 (0.9 to 67.8) | 1.1 (0.9 to 1.4) | 37.3 (1.3 to 67.1) | 0.8 (0.7 to 1.0) |
| Post-transplant features | |||||
| acute GVHD grade | |||||
| 0, I | 48 (24) | 4 (9) | 1.0 | 6 (10) | 1.0 |
| II to IV | 109 (54) | 39 (85) | 4.3 (1.5 to 12.7) | 53 (87) | 3.9 (1.6 to 9.7) |
| autologous/ id twin | 44 (22) | 3 (7) | 0.8 (0.2 to 3.9) | 2 (3) | 0.4 (0.1 to 1.9) |
| ADV infection | |||||
| no | 174 (86) | 39 (83) | 1.0 | 49 (77) | 1.0 |
| yes | 29 (14) | 8 (17) | 1.2 (0.5 to 2.9) | 15 (23) | 1.8 (0.9 to 3.7) |
| CMV infection | |||||
| no | 171 (84) | 34 (72) | 1.0 | 46 (72) | 1.0 |
| yes | 32 (16) | 13 (28) | 2.0 (1.0 to 4.3) | 18 (28) | 2.1 (1.1 to 4.1) |
| HSV infection | |||||
| no | 164 (81) | 37 (79) | 1.0 | 55 (86) | 1.0 |
| yes | 39 (19) | 10 (21) | 1.1 (0.5 to 2.5) | 9 (14) | 0.7 (0.3 to 1.5) |
| varicella virus infection | |||||
| no | 197 (97) | 46 (98) | 1.0 | 60 (94) | 1.0 |
| yes | 6 (3) | 1 (2) | 0.7 (0.1 to 6.1) | 4 (6) | 2.2 (0.6 to 8.0) |
| received acyclovir | |||||
| No | 39 (20) | 10 (22) | 1.0 | 10 (16) | 1.0 |
| Yes | 159 (80) | 36 (78) | 0.9 (0.4 to 1.9) | 51 (84) | 1.3 (0.6 to 2.7) |
| received amphotericin | |||||
| no | 72 (35) | 16 (34) | 1.0 | 17 (27) | 1.0 |
| yes | 131 (65) | 31 (66) | 1.1 (0.5 to 2.1) | 47 (73) | 1.5 (0.8 to 2.8) |
| acute kidney injury | |||||
| no | 122 (60) | 34 (72) | 1.0 | 30 (47) | 1.0 |
| yes | 81 (40) | 13 (28) | 0.6 (0.3 to 1.2) | 34 (53) | 1.7 (1.0 to 3.0) |
| Two weeks before death | |||||
| Bacterial infection | |||||
| no | 133 (66) | 30 (64) | 1.0 | 48 (75) | 1.0 |
| yes | 70 (34) | 17 (36) | 1.1 (0.6 to 2.1) | 16 (25) | 0.6 (0.3 to 1.2) |
| fungal infection | |||||
| no | 176 (87) | 44 (94) | 1.0 | 59 (92) | 1.0 |
| yes | 27 (13) | 3 (6) | 0.4 (0.1 to 1.5) | 5 (8) | 0.6 (0.2 to 1.5) |
| incidence of dialysis | |||||
| no | 152 (75) | 34 (72) | 1.0 | 46 (72) | 1.0 |
| yes | 51 (25) | 13 (28) | 1.1 (0.6 to 2.3) | 18 (28) | 1.2 (0.6 to 2.2) |
| incidence of intubation | |||||
| no | 122 (60) | 30 (64) | 1.0 | 43 (67) | 1.0 |
| yes | 81 (40) | 17 (36) | 0.9 (0.4 to 1.6) | 21 (33) | 0.7 (0.4 to 1.3) |
| Median (range) | Median (range) | Median (range) | |||
| mean bilirubinb | 4.8 (0.4 to 59.6) | 5.4 (0.6 to 43.8) | 1.1 (0.8 to 1.5) | 5.5 (0.5 to 52.1) | 1.1 (0.8 to 1.4) |
| mean serum creatinine | 1.52 (0.40 to 5.79) | 1.56 (0.27 to 4.57) | 0.9 (0.7 to 1.2) | 1.67 (0.55 to 4.74) | 1.1 (0.9 to 1.4) |
a
Estimate represents the ratio of odds for two patients, one 10 yr older than the other at transplant.
b
Estimate represents the ratio of odds for two patients, one with mean bilirubin 10 points higher than the other.