Table 5.
Effect of multivariate adjustment on the association between baseline creatinine clearance and rate of plaque growth
| Model 1: Unadjusted (model P = 0.01, R2 = 0.065) | ||
| Creatinine clearance quintile | Unadjusted β coefficient (95% CI) | P = 0.01 |
| q1(<23 ml/min/1.73 m2) | −0.22 (−0.34 to −0.10) | |
| q2 (23 to 29 ml/min/1.73 m2) | −0.10 (−0.22 to 0.02) | |
| q3 (29 to 35 ml/min/1.73 m2) | −0.10 (−0.22 to 0.02) | |
| q4 (35 to 43 ml/min/1.73 m2) | -0.07 (−0.19 to 0.05) | |
| q5 (>43 ml/min/1.73 m2) (ref.) | 0.0 | |
| Model 2: Adjusted for baseline plaque and center (model P < 0.0001, R2 = 0.255) | ||
| Creatinine Clearance Quintile | Unadjusted β Coefficient (95% CI) | P = 0.01 |
| q1(<23 ml/min/1.73 m2) | −0.19 (−0.29,−0.08) | P = 0.03 |
| q2 (23 to 29 ml/min/1.73 m2) | −0.09 (−0.19 to 0.02) | |
| q3 (29 to 35 ml/min/1.73 m2) | −0.07 (−0.18 to 0.03) | |
| q4 (35 to 43 ml/min/1.73 m2) | −0.06 (−0.16 to 0.04) | |
| q5 (>43 ml/min/1.73 m2) (ref.) | 0.0 | |
| Model 3: Adjusted for center, baseline plaque, duration of follow-up, number of ultrasounds, age, gender, smoking status, diabetes, blood pressure, LDL cholesterol, HMG-CoA reductase inhibitors, PTH, calcium binder use (model P < 0.0001, R2 = 0.296) | ||
| Creatinine Clearance Quintile | Adjusted β Coefficients | P = 0.02 |
| q1(<23 ml/min/1.73 m2) | −0.189 (−0.30, −0.08) | |
| q2 (23 to 29 ml/min/1.73 m2) | −0.10 (−0.21, 0.01) | |
| q3 (29 to 35 ml/min/1.73 m2) | −0.07 (−0.18, 0.03) | |
| q4 (35 to 43 ml/min/1.73 m2) | −0.06 (−0.17, 0.04) | |
| q5 (>43 ml/min/1.73 m2) (ref.) | 0.0 | |