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Fentanyl (A,B) and loperamide (C,D) concentrations in arterial plasma and the delta wave electroencephalogram (EEG) response in the absence (A,C) and presence of loperamide (B,D) in Sprague-Dawley rats (n = 4 per time point in pk studies, each animal (n = 4) was studied with pharmacokinetics (pk) drug and its competitive inhibitor except for n=3 for loperamide alone for EEG studies). Data presented as mean ± S.E.M.
