Skip to main content
. Author manuscript; available in PMC: 2010 Jan 1.
Published in final edited form as: Anesth Analg. 2009 Jan;108(1):149–159. doi: 10.1213/ane.0b013e31818e0bd1

Figure 6.

Figure 6

The effect of competitive substrates for protein transporters on opioid partitioning to lung and brain tissue and the hypothesized effect on transport proteins P-glycoprotein (P-gp) and organic anion peptide transporters (OATP) in determining pharmacokinetics of and by opioids. Values adjacent to transporter most hypothesized to be most affected. Solid line indicates no change in transporter activity, dashed line indicates reduced transporter activity, thinner dashed line indicates greater reduction in transporter activity