Figure 1.

Proposed model for E₂-induced transcription activation. The activation of the PR gene by ER may involve the activation of catalytic intermediary factors (IF). These IF, once modified due to interaction with the E₂–ER complex may promote PR gene transcription. For details, see Introduction and Discussion. E₂, estrogen; ER, estrogen receptor; E₂–ER, E₂-occupied ER; TX, transcription machinery;  , chromatin; , phosphorylation; IF, intermediate factors;   , nonactivated IF;  , activated IF. {/ANNT;2112n;4224n;10560n;102784n} {/ANNT;2112n;2112n;352n;105952n} {/ANNT;2112n;4224n;27808n;103136n} {/ANNT;2816n;2112n;26048n;105952n}