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Folate-deficient diet increases genomic uracil content of colon epithelial cells. Genomic uracil content of colon epithelial cells measured by mass spectrometry after 8 months of dietary intervention. Uracil was increased in folate-deficient samples, and this was significant for Ung−/− mice (n = 9 each, P= .03, Mann–Whitney U test). Average genomic uracil levels of Ung−/− mice were not significantly higher than in wild-type (WT) mice. KO, knockout.
