Fig. 3.
Cytochalasin B, alrestatin, and aminoguanidine diminish the effect of HG on ACE2 expression and ANG(1-7) levels. A: effect of 1 μmol/l cytochalasin B on ACE2 expression in the presence of HG. B: effect of 10 μmol/l aminoguanidine on ACE2 expression in the presence of HG. C: effect of 10 μmol/l alrestatin on ACE2 expression in the presence of HG (means ± SE; n = 3). †P < 0.05 vs. 0 h; *P < 0.05 vs. HG alone at the corresponding time points. D: effect of inhibitors on endogenous ANG(1-7) formation (means ± SE; n = 3). †P < 0.05 vs. vehicle in the presence of NG; *P < 0.05 vs. vehicle in the presence of HG; #P < 0.05 vs. the corresponding treatment in the presence of NG.