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Arterial injection of spingosine-1-phosphate (S1P) is unable to diminish histamine-induced macromolecular leakage of cremaster venular microvessels. Changes in fluorescence intensity were measured after injection of vehicle (n = 11) or S1P (n = 3–5 for each dose). Microvascular leakage was assessed by measurement of fluorescence intensity of FITC-albumin in extravascular space. Values are means ± SE.
