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. Author manuscript; available in PMC: 2009 Feb 9.
Published in final edited form as: Cold Spring Harb Symp Quant Biol. 2007;72:243–250. doi: 10.1101/sqb.2007.72.038

Figure 1.

Figure 1

Model of the molecular clock feedback loops in Drosophila. The clock is composed of two interconnected transcriptional-translational feedback loops. (A) In s-LNVs, cry is not required for rhythms and is omitted from the model, although it acts as a cell-autonomous photoreceptor in these cells. (B) In peripheral clocks, CRY has an important clock role and acts as a transcriptional repressor of CLK/CYC activity in conjunction with PER. Because cry expression is regulated by VRI and because VRI- and PDP1-binding sites are very similar, cry is probably also regulated by PDP1 (dashed line).