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The sample sizes required under the additive and multiplicative models for the secondary outcome – functional patency
| Total sample size | ||||
|---|---|---|---|---|
| Additive model | Multiplicative model | |||
| Patency failure rate at 6 months for placebo group | unadjusted | adjusted | unadjusted | adjusted |
| 40% | 874 | 1455 | 1156 | 1812 |
| 50% | 620 | 1034 | 820 | 1297 |
| 60% | 452 | 752 | 596 | 941 |
(Unadjusted and adjusted refer to the calculations of sample size without and with adjustment for loss to follow-up (5%), drop-in (15%) and drop-out (5%))
