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. 2009 Feb 16;4(2):e4496. doi: 10.1371/journal.pone.0004496

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Koslowski et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Both colour schemes (a and b) illustrate the linkage disequilibria. The variants are listed in the upper part of a and b, respectively. Haplotypes for TCF-4 (TCF7L2) rs3814570 (SNP1), rs10885394 (SNP2), rs10885395 (SNP3) and SNPs associated with diabetes in the Vienna cohort are shown in a. A missing number for D′ or r² equals 1. Figure 2b: HapMap data based haplotype blocks and linkage disequilibria (LD) for TCF-4 (TCF7L2) polymorphisms. The intensity of red colouring in b is proportional to the extent of D′ or r ² respectively and a missing number for each of them equals. The observed SNP in the putative promoter region is not part of any significant haplotype block.